Neuronal Aging – Is it reversible?

The main risk factor for neurodegenerative disorders, like Alzheimer disease, is aging. At molecular level, aging correlates, in peripheral tissues and the central nervous system with epigenetic changes at chromatin (histones DNA) of aged cells. These can be reverted by expression the, so called, Yamanaka factors (YF). YF reprogram (rejuvenate) old cells to structural functional characteristics young In case system, upon expression, an increase cognitive capacity found. Our future objective, extrapolate results found mice human being, will look simple small chemical compounds a similar capacity, that YF, revert during development.